作者 主题: 【CF】基因技术规则、基因修复、显性基因调整 P155-158  (阅读 11327 次)

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基因技术规则 GENETECH RULES

基因疗法基础 GENE THERAPY BASICS

在《暗影狂奔》中,“基因疗法”这个术语指的是多种用于转变和粘贴细胞和组织中基因信息,达到想要的效果的技术。这通常是通过纳米体、特制逆转录病毒和其他在细胞层面改变病人DNA的媒介完成的。接受基因疗法时,病人要浸入营养罐中一段时间,同时医学洁净室能防止生物因子或CFD影响的纳米体入侵。具体的治疗程序差距很大,但它们的末端作用、治疗次数和价格都很相似。基因疗法的价格包括了医疗支持、住院和为目标定制诊疗方案的花费。
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In Shadowrun, the term gene therapy describes the various techniques used to transfer and splice genetic information into cells and tissues to achieve a desired effect. This is usually achieved by having nanites, custom designed retroviruses, and other vectors simultaneously alter the patient’s DNA on a cellular level. Patients spend their time in gene therapy immersed in a nutrient tank, while medical clean-room protocols prevent any contamination by biological agents or CFD-infected nanites. Specific procedures are many and varied, but their end effects, treatment times, and prices are very similar. The cost of gene therapy includes medical supplies, hospitalization, and tailoring the treatment to the subject.

人对自然 MAN VS. NATURE
不像赛博改造或生体改造导致的精华损失,基因改造导致的精华损失不只是侵入。这种情况下,它部分来说也是由这些治疗程序的异质本质导致的。法师会说这是由于作为所有活物的一部分的魔法流被打断了。没有基因疗法能够例外——无论是把病人变回之前的自己,已知自然出现的显形性状调整,还是使用来源于自然设计的转基因治疗。泛人类不只是他们血肉骨的总和,无论是科学还是魔法目前都无法解释或者阻止基因改造导致的精华损失。
所有的基因技术都是永久的。它不能之后被移除,所以由于基因疗法导致的精华损失也是永久的,即便是在再生治疗(p. 157)中也是一样。如果之后的殖装或其他东西使基因技术殖装无效,也是如此——并没有可以填补的精华空洞。基因技术是永久的,所以小心选择,而且庆幸至少它没有让你被器官贩子盯上。
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Unlike Essence loss due to cyberware or bioware, Essence loss from geneware is not just a matter of invasiveness. In this case, it’s also due in part to the foreign nature of these procedures. A magician would say that it’s due to a disruption of the natural mana flow that is part of all living things. No genetic therapy can avoid this—not genetic treatments that restore patients back to their former selves, nor phenotype adjustments that have been known to occur in nature, nor transgenic treaments that use genes that originate in natural designs. A metahuman is more than a sum of their flesh, blood, and bone, and neither science nor magic has yet been able to explain or prevent genetech’s Essence costs.
All genetech is permanent. It cannot be removed at a later date, so the Essence loss due to gene therapy is also permanent, even under the revitalization treatment (p. 157). This is also true if a later augmentation or other event renders a genetech augmentation useless—there is no Essence hole remaining to be filled. Genetech is forever, so choose carefully, and be glad that at least it doesn’t make you more interesting to organleggers.   
« 上次编辑: 2018-04-12, 周四 01:05:48 由 妖猫 »




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Re: 【CF】基因技术规则 P155-156
« 回帖 #1 于: 2018-04-11, 周三 19:33:58 »
基因修复 GENETIC RESTORATION

基因修复即用于治愈疾病、移除年老的负面作用或是其他改善健康状况的医学基因治疗。它们的作用即恢复并提高身体自身的基因基线。
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Genetic restorations are medical genetic treatments to cure diseases, remove negative side effects of aging, or otherwise strengthen health. They work to restore and boost the body’s own genetic baseline.

治疗基因改造 THERAPEUTIC GENETICS

治疗基因改造是一个人能获得的最不复杂、最古老,理解最深的基因改造。它们特别的一点是不会伤害精华。其中许多能够矫正遗传的缺陷和失调。财务状况让那些需要这些疗法的人无法得到它,这就是世界。下面的列表上有一些例子,但这决不是全部。
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Therapeutic genetics are the least complex, oldest, and best understood genetic alterations an individual can get. They are unique in that they do not damage Essence. Many correct inherited disabilities and disorders. It is the way of the world that financial means prevent all who need these therapies from acquiring them. Below is a list of a few examples, though it is by no means exhaustive.
癌症预防治疗:已经发现如果特定基因得到表现,大多数癌症的发病率会显著上升。常规筛查能够查明这些基因,治疗能够很快很容易(虽然可能不便宜)地在癌症发展之前消灭掉这一风险。一旦癌症发病,这些疗法就不再有效了。
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Cancer Prevention Treatment: It has been found that the risk of developing most cancers is greatly increased if certain genes are present. Routine screening detects these genes and treatments can quickly and easily (although not cheaply) eliminate this risk before cancer ever develops. Once cancer has developed, these therapies are sadly no longer effective.
色盲症:色盲症是基因缺陷的结果,影响了接收光并向视神经传递信息的视锥细胞。这一缺陷在人口中有着相当的比例,尤其是在男性中。调整编码感光色素的基因是个修正这一缺陷的相对简单的改造。
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Color Blindness: A result of a genetic fault that affects the retinal cones that receive light and pass information on to the optic nerve, this defect is present in a significant portion of the population, primarily males. Adjustment of the genes that code for photopigments is a comparatively simple alteration that corrects this disability.
矫正基因疗法:人类种群中最常见的基因失调中的大部分都能够治疗。通常会在新生儿基因筛查中发现这些失调,立刻进行治疗。在所有的公司卫生保健政策下,这样的基因筛查和治疗都是标准流程。最常进行的矫正是囊肿性纤维化、亨廷顿病、唐氏综合征、肌肉萎缩症、镰状细胞性贫血、乳糜泻和食物不耐受。
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Corrective Gene Therapy: Treatments are available for many of the most common genetic disorders found in human populations. These disorders are usually found during neonatal gene screening and treated immediately. Such gene screening and treatment is standard with all corporate health-care policies. The corrections most often performed are for cystic fibrosis, Huntington’s disease, Down syndrome, muscular dystrophy, sickle-cell anemia, celiac disease, and food intolerance.
« 上次编辑: 2019-04-17, 周三 13:07:04 由 妖猫 »




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Re: 【CF】基因技术规则 P155-156
« 回帖 #2 于: 2018-04-11, 周三 23:17:11 »
回春治疗 REJUVENATION TREATMENT

每个回春治疗都需要一个主要的疗程,通常还有每六个月一次的维护疗程,从而确保治疗完全生效。取决于具体使用的回春治疗,它可以让身体恢复年轻强健,或是无需复原身体地延长预期寿命。无论执行的是哪个治疗,回春能够进行的次数是有限的,直到累积的精华损失造成死亡。
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Each rejuvenation treatment requires one major therapy session, usually followed by a number of maintenance sessions every six months for the next three years to ensure that the treatment is wholly effective. Depending on what kind of age rejuvenation treatment is applied, it can restore physical youth and vigor, or expand life expectancy without restoration of physical health. Regardless of which treatment is administered, age rejuvenation can only be performed a limited number of times before the cumulative Essence loss takes its toll.
就像所有的基因技术,回春治疗是永久的,但即便是这么强大的治疗都不能完全阻止所有的岁月磨砺。比如,脑化学很大程度上不能被改变,否则病人就有失去记忆和习得的运动技巧的风险。像是阿兹海默症或帕金森症这种取决于神经元间关系而非神经元自身的状况无法被回春矫正。
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Like all genetech, rejuvenation treatments are permanent, but even a treatment this powerful cannot totally prevent all of the ravages of time. Brain chemistry, for example, must be largely unaltered or the patient runs the risk of losing memory and acquired motor skills. Conditions such as Alzheimer’s or Parkinson’s diseases that rely on the connections between neurons rather than the neurons themselves cannot be corrected by rejuvenation.
莱昂疗法:莱昂疗法对整体健康有着显著影响,因为它试图反转身体的自然过程——变老、死亡。这一疗法重置了控制年老的基因机制,有效地把细胞生命重启到它年轻的全盛时期。在治疗结束后,病人的身体年龄会恢复到大约21岁。
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Leónization: Leónization has a significant impact on holistic health as it attempts to reverse the natural processes of the body—aging and death. The therapy resets the genetic mechanism that controls aging, effectively rebooting cell life to its youthful prime. After treatment, the patient is restored to a physical age of approximately twenty-one.
寿命延续:不像其他治疗,寿命延续不需要后续疗程。通过减慢变老过程,消除某些已知的老化效果,一个疗程就足以把预期寿命增加10年。每个后续的寿命延续都只会拥有前一个的一半效果,下一个延续5年,再下一个则是30个月,如此继续。
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Lifespan Extension: Unlike other treatments, lifespan extension doesn’t require follow-up sessions. One therapy session is enough to increase the life expectancy up to ten years by slowing down the aging process and eliminating some of the known effects of aging. Each subsequent lifespan extension has half the effect of the previous, expanding the lifespan by up to five years, then around thirty months, and so on.
身体活力:莱昂疗法恢复身体年龄,这一疗法则处理年老带来的副作用——也就是所谓的让人“服老”的东西——而无需改变年龄增长的过程。这能够提高生活质量,从而使上年纪的病人重获青少年的活力与健壮。
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Physical Vigor: While Leónization restores physical age, this treatment deals with the side effects of aging— often called the “felt age” —without altering the aging process. This improves quality of life and results in elderly patients with the vigor and robustness of an adolescent.
强化治愈:强化治愈是一个能够把身体恢复到基因完全健康的全身疗法。病人CM的全部伤害会被完全治愈,无论其来源如何,但这只是其副作用而已。它真正的作用是完全再生受伤的器官、粉碎的骨骼、断肢、受损的神经。这一治疗不会修复受损的赛博改造或纳米殖装——事实上,这些系统在的时候,治疗要为纳米体治疗多花25%的费用,从而使治愈中的身体不会拒斥机械。强化治愈也可以被用来修复生体改造的系统,费用也提高25%。
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Augmented Healing: Augmented healing is a wholebody therapy that restores the body to its full genetic health template. The patient’s Condition Monitors are healed of all damage regardless of the source, but that’s just a side effect. The real benefit is the complete regrowth of injured organs, crushed bones, severed limbs, and damaged nerves. The treatment doesn’t repair damaged cybernetics or nanoware—in fact, when these systems are present, the treatment costs an additional twenty-five percent for the nanite treatment to keep the healing body from rejecting the machines. Augmented healing can also be used to repair bioware systems, increasing the cost by twenty-five percent.
细胞修复:这一特殊再生治疗能修复神经毒素、辐射、魔法和其他极端来源的永久性细胞损伤。每次治疗能够修复由于疾病或严重身体创伤造成的1点属性降低,由于能量汲取(Street Grimoire p.195)或精华吸取(核心书 p.396)造成的1点精华损失,或是把萎缩特质(Run & Gun p.169)降低1级。如果想要治愈多点伤害,就必须多次进行治疗。这不会修复作为主体自身的基因表现一部分的遗传问题或缺陷。
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Cellular Repair: This specialized regenerative treatment repairs permanent cellular damage caused by neurotoxins, radiation, magic, and other extreme sources. Each treatment can restore one point of any attribute lost due to disease or severe physical trauma, one point of Essence lost to Energy Drain (p. 195, Street Grimoire) or Essence Drain (p. 396, SR5) powers, or reduce the Blighted quality (p. 169, Run & Gun) by one level. If individuals want to heal multiple points of damage, they have to take the treatment multiple times. It will not fix hereditary problems or disabilities integral to the subject’s own genetic expression.
新生:新生是一次技术突破,能修复侵入性植入造成的精华损失。环球全能科技成功将其机制保密,让遗传学家猜测这一效果是通过某种“基因风水”达到的。科学家与法师一同致力于通过基因层面重塑DNA,重新排列患者的灵光,修复对灵光造成的伤害,平衡身体系统,恢复精华。
新生的每次治疗能够再生0.1的精华。这一疗法可以恢复由于已经被移除的植入体或是成瘾造成的精华损失。这一技术不能恢复仍然存在的植入体或进行中的治疗造成的精华损失,而且它不能修复基因改造耗费的精华。损失的魔法或共鸣属性不会返还,而最大魔法/共鸣属性的下降仍然奏效。这一治疗花费一个月,但患者只需要在诊所里呆7天,之后就等这个月结束,它开始生效。
译注:成瘾什么时候会造成精华损失了……

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Revitalization: Revitalization is a breakthrough that repairs Essence loss derived from invasive implantation. Universal Omnitech has been successful in keeping the mechanism a secret, leaving geneticists to speculate that the effect is achieved by performing some kind of “genetic feng shui.” Scientists work with a magician to realign the patient’s aura by genetically remodeling DNA to repair damage to the aura and balance to the body’s systems, restoring Essence.
Revitalization regenerates Essence at a rate of 0.1 Essence per treatment. The treatment can restore Essence lost to implants that have been removed and to addiction. The technique cannot restore Essence for implants or treatments that remain in place, and it cannot repair Essence from gene therapies. Magic or Resonance points lost are never returned, and reductions to the maximum Magic/Resonance attribute remain in effect. The treatment takes one month, but patients need only spend seven days in a clinic and then wait the rest of the month for it to kick in.

« 上次编辑: 2019-04-17, 周三 13:07:15 由 妖猫 »




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Re: 【CF】基因技术规则 P155-156
« 回帖 #3 于: 2018-04-12, 周四 00:02:29 »
显性基因调整 PHENOTYPE ADJUSTMENT

所有的显性基因调整都需要与基因疗法相同的治疗环境。它包括所有只涉及自然的泛人类基因添加或修改的基因变化。
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All phenotype adjustments require the same treatment environment as gene therapy and include all genomic changes that involve the addition or modification of only natural, metahuman genes.

DNA伪装 DNA MASKING

把自己的基因伪装到基因扫描器无法辨识,或是伪造数据银行信息或SIN记录,从而躲避识别,这可是一件高度非法的事情。无需多言,DNA伪装在黑诊所里需求很高,满足地下世界、暗影、间谍组织和特殊执行部门的需要。
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Making oneself unidentifiable to gene scanners or faking data bank information or SIN registry to evade positive identification is highly illegal. Needless to say, DNA masking is in high demand at black clinics catering to the underworld, the shadows, espionage organizations, and special ops divisions.
基因擦:这一治疗的主要基因疗法过程是把一个标签植入身体的神经递质中,在他们没有接收到身体通常的神经化学信号时触发,加速细胞死亡——使得上皮细胞和毛发在离开身体后更快分解。作为结果,拥有这一治疗的角色留下的生物追踪证据在5分钟之后就会退化,使它无法作为基因档案或仪式样本。
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Genewipe: This treatment is a major genetherapeutic procedure that inserts a tag into the body’s neurotransmitters that triggers accelerated cell death whenever these cease to receive regular neurochemical signals from the body—causing epithelial cells and hair to decompose more rapidly when they are removed from the body. As a consequence, biological trace evidence left by characters with this treatment irrevocably deteriorates after five minutes, rendering it useless for genetic profiling or ritual samples.
假面:这一治疗会改变角色的部分非编码序列,使得DNA扫描器在搜索正常的基因组ID数据库时不会正确识别。虽然大多数DNA扫描器会显示没有找到,但等级6或以上的DNA扫描器会认出缺少了特定标记元素,并且报告需要用其他手段进行进一步的身份认证。
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Masque: This treatment changes parts of the character’s non-coding sequence so that a DNA scanner will not produce a positive identification when searching normal genome ID databases. While most DNA scanners will report a not-found result, scanners with Device Rating of 6 or more will recognize the absence of certain marker elements and report that further identification is required by other methods.
重印:重印建立了一个新的基因档案,改变在基因组中经常被检测的多态性,创造了一个新且独特的基因指纹。只有这个新的模式会被基因扫描器或基因指纹鉴定辨认出来。即便整个基因组序列都被检查了,其身份也无法清晰地通过基因辨认出来。
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Reprint: Reprinting establishes a new genetic profile changing commonly tested polymorphisms within the genome to create a new and unique genetic fingerprint. Only the new pattern is recognized by gene scanners or identified by genetic fingerprinting. Even if full genome sequencing is performed, there is no way to unambiguously identify the individual genetically.
洗牌:一个人拥有的基因修改的数量和类别可以通过小心地重新组织基因结构进行隐藏。这需要对患者的基因组进行广泛的分析,从而找出最适合藏匿改造的位置。这并非万无一失。这一改造提高1点通过基因指纹分析辨认出基因修改的阈值。
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Shuffle: The amount and types of genetic modifications that a subject possesses can be concealed by careful reorganization of gene structures. This requires an extensive analysis of the patient’s genome in order to set up the best places to conceal the modifications. It is not foolproof. This adjustment raises the threshold for identifying genetic modifications through genetic fingerprinting by 1.

基因最佳化 GENETIC OPTIMIZATION

基因最佳化通过调整负责特定属性发展的基因,永远地提高肉体和精神的潜能。每次你进行基因最佳化时,你选择的物理或精神属性的自然属性最大值提高1点。每个属性只能这么操作1次。就像优越属性特质(核心书 p.72),这一治疗不会提高属性本身——意味着你仍然需要如常花费业力来提高属性(核心书 p.103角色提升)。这一调整与优越属性完全兼容。
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Genetic optimization permanently increases physical and mental potential by tweaking the genes responsible for the development of a given attribute. Each time you undergo gene optimization, you raise your maximum natural attribute in one Physical or Mental attribute of your choice by one point. Each attribute can only be perfected in this manner once. Like the Exceptional Attribute quality (p.72, SR5), this treatment does not raise the attribute itself—meaning you still have to spend Karma to raise the attribute, as usual (Character Advancement, p.103, SR5). This adjustment is fully compatible with Exceptional Attribute.
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Re: 【CF】基因技术规则 P155-156
« 回帖 #4 于: 2018-04-12, 周四 00:36:01 »
显性基因变化 PHENOTYPIC ALTERATION

显形基因变化能够创造几乎任何对身体的改变,只要不超过泛人类的标准。这一治疗可以加长肢体、改变肤色、添加角、调整毛发、改变总体身材等等。能做到的极限取决于GM的判断,但一个不错的参考是不允许明显的非人类改变,比如额外肢体、非泛人类的感觉器官、非泛人类特征,或是更稀奇古怪的东西。特定的变化可能会与器官置换不兼容,诸如赛博义肢、赛博眼、生体改造皮肤或是整容改造。以下改变是常见的显性基因变化。
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Phenotypic alteration can create virtually any change to the body within the limits of metahuman norms. This treatment can elongate limbs, change skin tone or color, add horns, modify hair, change overall build, and so forth. The limits are left to the gamemaster’s judgment, but a good guideline is to disallow obviously inhuman changes such as extra limbs, non-metahuman sensory organs, non-metahuman features, or anything more fanciful. Specific changes may be incompatible with organ replacements such as cyberlimbs, cybereyes, bioware skin, or cosmetic modifications. The following changes are common phenotypic alterations.

整容变化:有许多专注于美容(取决于你问的是谁)的基因调整。包括多加一层睫毛的双行睫调整、移除或添加内眦皮、减少皱纹、瞳色(包括同一虹膜不同部分的变化)、发色和纹理、消除秃顶、肤色、巨魔角的形状、巨魔和兽人獠牙的形状等等,随你想象,只要在泛人类表现型内即可。
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Cosmetic Alteration: A variety of genetic modifications that focus on beautification (depending on who you ask) are available. Included are a distichia modification that adds a double row of eyebrows, epicanthic fold removal or addition, wrinkle reduction, eye color (including changes to different parts of the same iris), hair color and texture, baldness elimination, skin color, horn shape for trolls, tusk shape for orks and trolls, and so on limited only by the imagination and the metahuman phenotype.
移除指纹:可以通过阻碍导致皮嵴生长的自然过程来完全消除指纹或掌纹。这产生了无纹路的手指、脚趾、手掌和脚掌。指纹扫描器会报告必须通过其他手段进行识别。
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Print Removal: Finger- or palm-prints can be completely removed by interfering with the natural process that leads to the development of skin ridges. This yields patternless fingers, toes, palms, and feet. Print scanners will report that the subject must be identified by a secondary method.
泛人容貌:这一治疗在基因层面把你变为接近某个特定泛形态(或泛变种)的样子,而不会真的获得任何优势或劣势。举例来说,这允许真的装作精灵的人类看上去很像精灵,不过他不会获得低光视觉,也不会长寿。
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Metaposeur: This treatment genetically changes you to physically resemble a particular metatype (or metavariant), without actually granting any of their native advantages or disadvantages. For example, this enables a human elf-poseur who really wants to look like an elf to do so, though he gains no low-light vision or longevity.

引用
可选规则:显性基因变异 OPTIONAL RULE: PHENOTYPIC VARIATION
非常少数的人自然地表现出了这些变种表现型,而有些显性基因稀少到了亿分之一的程度。一个显形基因调整可以在角色创建阶段作为正面特质选择(需要GM同意),业力花费等于{(基因调整价格/2,000新円,向上取整)+3}。作为天生变异,这一特质不会影响你的精华。
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An exceedingly small number of individuals express these variant metahuman phenotypes naturally, with some phenotype being as rare as one in a billion. One phenotype adjustment can be taken as a Positive quality during character creation (with gamemster approval) with a Karma cost equal to the cost of the adjustment divided by 2,000 nuyen, rounded up + 3. As a natural mutation, this quality doesn’t affect your Essence.

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